Here's how I got authenticated SMTP working for our environment. This is pretty useful if you need to send external mails. My Kit: System Center Operations Manager 2007 R2 CU5 Exchange Server 2010 SP1 RU6 Make/choose an AD account with an email address which will send your notifications. In Ops Manager create a Windows Account using the credentials created above. Assign these credentials to the Notifications Account Run As Profile. Set up a channel to use authenticated SMTP using the email address of the account used in step 1. If you want/need create an Exchange Receive Connector with Windows Authentication and Exchange Users permissions group. Test and enjoy. This is pretty simple really but took me a while to figure out as I failed to see that my Notification Account didn't have the email address I set as the Return Address in the Notification Channel wizard.